GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2243480 | 1 | rs2707831 | chr7:66062511 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.82 | 2.04E-6 | Diabetic kidney disease |
| BLCA | cis | rs1499614 | 1 | rs2707832 | chr7:66136549 | CCT6P1 | chr7:65216092-65228661:+ | 0.38 | 5.22 | 2.94E-7 | Gout |
| BLCA | cis | rs1499614 | 1 | rs2707838 | chr7:66159201 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.69 | 3.85E-6 | Gout |
| BLCA | cis | rs1499614 | 1 | rs2707840 | chr7:66158015 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.71 | 3.42E-6 | Gout |
| BLCA | cis | rs2243480 | 1 | rs2707844 | chr7:66059509 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.82 | 2.04E-6 | Diabetic kidney disease |
| BLCA | cis | rs2294008 | 1 | rs2717562 | chr8:143776668 | LY6D | chr8:143866298-143868008:- | 0.22 | 4.67 | 4.19E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2717562 | chr8:143776668 | PSCA | chr8:143761875-143764142:+ | 0.52 | 16.19 | 2.64E-45 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs30187 | 1 | rs27529 | chr5:96126308 | ERAP1 | chr5:96096515-96149837:- | -0.49 | -10.44 | 1.26E-22 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs27529 | chr5:96126308 | ERAP2 | chr5:96211644-96255398:+ | 0.33 | 5.64 | 3.39E-8 | Ankylosing spondylitis |
| BLCA | cis | rs9457247 | 1 | rs2757042 | chr6:167371234 | RNASET2 | chr6:167343008-167412795:- | 0.22 | 4.57 | 6.71E-6 | Crohn's disease |
| BLCA | cis | rs9457247 | 1 | rs2757047 | chr6:167374489 | RNASET2 | chr6:167343008-167412795:- | 0.22 | 4.7 | 3.57E-6 | Crohn's disease |
| BLCA | cis | rs2764743 | 1 | rs2764743 | chr16:20031205 | LOC81691 | chr16:20817767-20860989:+ | 0.4 | 3.86 | 0.000136 | IgG glycosylation |
| BLCA | cis | rs2762051 | 1 | rs2765766 | chr13:50805755 | CAB39L | chr13:49882787-50018221:- | 0.24 | 4.59 | 5.93E-6 | Celiac disease |
| BLCA | cis | rs9457247 | 1 | rs2769347 | chr6:167371737 | RNASET2 | chr6:167343008-167412795:- | 0.22 | 4.67 | 4.22E-6 | Crohn's disease |
| BLCA | cis | rs9457247 | 1 | rs2769352 | chr6:167378619 | RNASET2 | chr6:167343008-167412795:- | 0.22 | 4.49 | 9.34E-6 | Crohn's disease |